Wednesday, November 12, 2008 |
12.00 |
Registration |
13.45 |
Opening Remarks
Graham Collingridge, University of Bristol, UK |
13.50 |
IUPHAR and ligand-gated ion channel receptors
Michael Spedding, Institut De Recherches Servier, France |
Ionotropic glutamate receptors 1 – AMPARs
Chair: Graham Collingridge, University of Bristol, UK |
14.00 |
The beginnings of glutamate receptor pharmacology and the idiosyncrasies of nomenclature
David Lodge, University of Bristol, UK |
14.30 |
A genetic analysis of the subunit composition of synaptic AMPA receptors
Roger Nicoll, University of California, San Francisco, USA |
15.00 |
New functions for AMPAR surface trafficking in controlling fast synaptic transmission
Daniel Choquet, University of Bordeaux, France |
15.30 |
AMPA receptors and antidepressants
Michael Spedding, Institut De Recherches Servier, France |
16.00 |
Refreshment Break |
Ionotropic glutamate receptors 2 – AMPARs and NMDARs
Chair: Michael Spedding, Institut De Recherches Servier, France |
16.30 |
AMPA/NMDA mediated plasticity in the pathophysiology and treatment of severe mood disorders
Husseini Manji, National Institutes of Mental Health, USA |
17.00 |
Therapeutic potential of N-methyl-D-aspartate (NMDA) receptor antagonists
Chris Parsons, Merz Pharmaceuticals GmbH, Germany |
17.30 |
Role of SNARE proteins in trafficking of postsynaptic NMDA receptors
Susanne Zukin, Albert Einstein College of Medicine, USA |
18.00 |
Region-selective NMDA and AMPA receptor knockouts in mice: Behavioral consequences
Peter Seeburg, Max-Planck-Institute for Medical Research, Germany |
18.30-20.00 |
Poster Session I & Reception |
Thursday, November 13, 2008 |
GABAA receptors
Chair: Heinrich Betz, Max Planck Institute for Brain Research, Germany |
09.00 |
GABAA Receptors: Subtypes provide diverse functions and pharmacology
Richard Olsen, University of California, Los Angeles, USA |
09.30 |
Structure-function of inhibitory neurotransmitter receptors
Trevor Smart, University College London, UK |
10.00 |
Alcohol actions on GABAA receptor subtypes
Martin Wallner, University of California, Los Angeles, USA |
10.30 |
Refreshment Break |
GABAA receptors
Chair: Richard Olsen, University of California, Los Angeles, USA |
11.00 |
Alterations in GABAA receptor biogenesis and function in idiopathic generalized epilepsies
Robert MacDonald, Vanderbilt University Medical Center, USA |
11.30 |
Linking structure to function in GABAA receptors
Cindy Czajkowski, University of Wisconsin, Madison Medical School, USA |
12.00 |
GABAA receptor subtype-specificity of drug action: A paradigm leading to novel therapeutic strategies
Uwe Rudolph, McLean Hospital, Harvard University, USA |
12.30 |
Lunch |
Hot topics
Chair: John Peters, University of Dundee, UK |
14.00 |
8 shorts talks – S1 – S8 (15 mins each) |
16.00 |
Refreshment Break |
P2X receptors
Chair: Neil Millar, University College London, UK |
16.30 |
P2X receptor gating and permeation
Baljit Khakh, University of California, Los Angeles, USA |
17.00 |
Purinergic neural/glial interactions in chronic pain states
Michael Jarvis, Abbott Laboratories, USA |
17.30 |
Molecular pharmacology of P2X receptors
Richard Evans, University of Leicester, UK |
18.00-20.00 |
Poster Session II & Reception |
Friday, November 14, 2008 |
Nicotinic receptors
Chair: John Peters, University of Dundee, UK |
09.00 |
The nicotinic acetylcholine receptor: A model of allosteric membrane protein
Jean-Pierre Changeux, Institut Pasteur, France |
09.30 |
Molecular characterization of neuronal nicotinic acetylcholine receptors and the molecular chaperone RIC-3
Neil Millar, University College London, UK |
10.00 |
Nicotinic receptors: Fast channels and slow synapses
Robin Lester, University of Alabama at Birmingham, USA |
10.30 |
Refreshment Break |
5-HT3 receptors & glycine receptors
Chair: Jean-Pierre Changeux, Institut Pasteur, France |
11.00 |
The ABC of 5-HT3 receptors
Sarah Lummis, University of Cambridge, UK |
11.30 |
Structural determinants of single channel conductance and ion selectivity in the 5-HT3 receptor
John Peters, University of Dundee, UK |
12.00 |
Inhibitory and excitatory glycine receptors
Heinrich Betz, Max Planck Institute for Brain Research, Germany |
12.30 |
Investigating glycine receptor structure and function using voltage clamp fluorometry
Joe Lynch, University of Queensland, Australia |
13.00 |
Lunch |
Ionotropic glutamate receptors 3 - KARs
Chair: David Lodge, University of Bristol, UK |
14.00 |
Glutamate receptor ion channels: Structure and mechanism of allosteric regulation
Mark Mayer, NICHD, USA |
14.30 |
Discovery of subunit selective kainate receptor agonists and antagonists
David Jane, University of Bristol, UK |
15.00 |
Functions of kainate receptors in the hippocampus
Graham Collingridge, University of Bristol, UK |
15.30 |
Refreshment Break |
16.00 |
Role of kainate receptors in synaptic transmission, plasticity, learning and mental illness
Stephen Heinemann, Salk Institute, USA |
16.30 |
Mechanisms of synaptic facilitation by presynaptic kainate receptors
Christophe Mulle, University of Bordeaux, France |
17.00 |
Noncanonical signaling and trafficking of kainate receptors
Juan Lerma, Instituto de Neurociencias de Alicante, Spain |
17.30 |
Closing Remarks |
